Namaskaram to all the Students of Jyotish

The chart shared is of a native who has Down Syndrome & Autism.
To understand the mental illnes better from such charts my focus was on Moon, Mercury, Jupiter, 5th house/5th Lord.
I had a some doubts about this chart, therefore reaching out to this learned forum.

1. What are the deeper interpretive principles we must apply in Drekkana to understand cognitive or neurological disorders when the grahas don’t appear obviously afflicted? Though in D3 we do find Moon’s conjunction with 6th lord, mercury is 12th lord, jupiter 6th lord, but D3 didn’t exhibit clear or strong mental affliction to me, possibly I could be missing something.

2. How much weight should be given to Rashi vs D3 vs. D9 vs D12 or D30 when diagnosing mental disorders like Down Syndrome?

3. If Rashi and Navamsa appear supportive of mental illness, but D3 shows different results, should we consider that sufficient to explain the condition? Or must affliction be visible across multiple charts to conclude karmic causes?