Sir I have a doubt regarding mutual aspects of ucha/ neecha grah for eg mars in 4th house and Jupiter in 10th house( both neech housewise).Are they cancelling debilation of each other? Want to understand how they behave in their mahadasha?

Sir, I have doubts about mutual aspects of planets. Sat (R) and Jup (R) in Virgo Lagna. Mer and Mars in Pisces 7H. All the four planets are aspecting each other without any other influence. Shouldn’t the aspects cancel each other out?